Acetazolamide is a class of carbonate anhydrase inhibitor drugs used for medical treatment of glaucoma, epilepsy, idiopathic intracranial hypertension, cystinuria, periodic paralysis, and dural ectasia.
In addition to glaucoma, acetazolamide is also reliable for epilepsy and as a diuretic (urine production enhancer).
Acetazolamide is also used to treat drug-induced edema, edema caused by heart failure, epilepsy centrencephalic and reduce interocular pressure after surgery
Information About Acetazolamide
The preparation of Anti-glaucoma
Forms of drugs:
Adults and children
As a diuretic a preoperative therapy for closed-angle glaucoma
Treat open-angle glaucoma, secondary glaucoma, and acute closed angle glaucoma
How Drugs WorkAcetazolamide works by blocking the enzyme carbonic anhydrase activity in order to reduce pressure in the eye area for patients with glaucoma.
Dose of AcetazolamideTreatment of open-angle glaucoma in adults
> Dose starting from 250 mg/day in divided doses to 1-4 tablets.
Acute angle-closure glaucoma (congestive) and secondary
> 250-1000 mg per 24 hours. Doses above 250 mg daily given in divided doses.
Secondary glaucoma treatment and therapy before surgery
> Dose starting from 250 mg every 4 hours.
Diuretics for congestive heart failure and edema due to drugs
> Usually starts with 250-375mg once daily.
Diuretics for premenstrual tension
> Usually 125-375mg once daily.
> 250-1000 mg per 24 hours in divided doses
Acetazolamide Side Effects
- Some common side effects after taking Acetazolamide are dizziness, drowsiness, fatigue, nausea, and diarrhea.
- You may also feel the loss of appetite, dehydration, the frequency of urination is more frequent, taste the metallic taste after taking the drug, tingling, and facial flushing.
Drugs InteractionAvoid coadministration with other drugs:
- Hypoglycemic, acetazolamide may decrease or increase blood glucose levels
- Quinidine, quinidine reduces the secretion of urine, thus increasing the potential toxicity
- Sodium bicarbonate, the potential for the formation of kidney stones
Caution & Warning
- Do not chew acetazolamide in capsule form because it can stop the action of the drug.
- Try to take the drug at the same time each day that does not easily pass the time taking medication.
- For patients who forget to take acetazolamide, are advised to drink so remember if the next dose schedule is not too close.
- Do not double the dose acetazolamide on next schedule to replace the missed dose.
- Not advised to stop taking acetazolamide suddenly without permission of your doctor.
- Inform your doctor if you experience conditions that resemble a rash on the skin caused by this drug nor the result of the other treatments that a doctor can determine the next treatment step.